CVRPII - Radioisotope Transfer System Unit
This system allows the operator to transfer the radioisotope activity from each target (up to 6 or 8 targets – this depends on the use of a 6 or 8-way valve) in different synthesis cells, guaranteeing the operator all the various transfer possibilities.
It is important to specify that the system is compatible with all types of cyclotrons, cells, modules as well as dispensing systems.
The system includes the following:
- RADIOISOTOPES TRANSFER SYSTEM UNIT VALVE
- RADIOISOTOPE TRANSFER LINE WASHING SYSTEM UNIT
- IONIZING CHAMBER FOR MEASURING RADIOISOTOPE ACTIVITY
- RADIOACTIVE SOLUTION He MIXING SYSTEM UNIT
- BUBBLE POINT TEST UNIT “FILTER INTEGRITY TEST”
The valves installed on this system can be in peek or steel and withstand high pressures (up to 100 bar), this guarantees the transfer of radioisotope activity from each target according to your needs.
- 1. Radioisotope transfer line washing system unit
This arises from the need to preserve the entire radioisotope transfer system. A constantly clean system increases the life of all the parts involved, especially the valves and transfer lines, as well as removing all residual activity within the system.
This system consists of a peristaltic pump connected on one side to a bottle of sterile PPI water and on the other side connected directly to the transfer system; it is possible to wash the transfer lines up to the module used for the synthesis, before and after each production.
It also allows you to perform microbiological sampling of the residual washing water correctly collected, so as to allow the monitoring of the microbial load present in the transfer lines, thus eliminating the cost of enriched water.
- 2. Ionizing chamber for radioisotope activity and linearity reading unit
This system consists of two valves, one two-way and the other three-way installed between two switching boxes. It allows the operator to perform a direct reading of the radioisotope activity produced at the end of the bombardment, for each target inside an ionization chamber, before sending the activity to the synthesis module.
This procedure allows the operator to have under control the data relating to the saturation yields of the targets involved.
- 3. Radioactive solution He mixing system unit
This system involves the use of inert hyperpure gas, in this case, Helium IP, exploiting its bubbling inside the radioactive solution contained in the mother vial before dispensing; this happens thanks to a pressure regulator and a two-way valve; it is important to remember that the gas before coming into contact with the solution is further filtered through a sterilizing filter (0.22 microns) before being conveyed inside the mother vial.
- 4. Bubble point test unity
In accordance with the requirements of the European Pharmacopoeia, the system provides for the execution of the bubble point test at the end of dispensing on the sterilizing filter used, directly in the dispensing cell; the process is controlled by the management-control software and can be performed:
- In manual mode (the operator types the required value)
- In automatic mode (the pressure gradually increases at regular intervals starting from 0 bar up to a maximum of 7 bar with steps of 0.2 bar)
The operator receives feedback directly from the flow and pressure sensors installed within the system which indicate the correct execution of the test; the software also creates a graph that indicates the exact bubble point of the sterilizing filter, the unit is controlled by an independent PLC that is easy to install and use.